2-hydroxymuconate-semialdehyde hydrolase

In enzymology, a 2-hydroxymuconate-semialdehyde hydrolase (EC number|3.7.1.9) is an enzyme that catalyzes the chemical reaction

:2-hydroxymuconate semialdehyde + H₂O $ightleftharpoons$ formate + 2-oxopent-4-enoate

Thus, the two substrates of this enzyme are 2-hydroxymuconate semialdehyde and H₂O, whereas its two products are formate and 2-oxopent-4-enoate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is 2-hydroxymuconate-semialdehyde formylhydrolase. Other names in common use include 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase, 2-hydroxymuconic semialdehyde hydrolase, HMSH, and HOD hydrolase. This enzyme participates in 5 metabolic pathways: benzoate degradation via hydroxylation, toluene and xylene degradation, 1,4-dichlorobenzene degradation, carbazole degradation, and styrene degradation.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1IUN, PDB link|1IUO, PDB link|1IUP, PDB link|1UK6, PDB link|1UK7, PDB link|1UK8, PDB link|1UK9, PDB link|1UKA, PDB link|1UKB, and PDB link|2D0D.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|54004-61-4."

Gene Ontology (GO) codes