Lipoyl synthase

In enzymology, a lipoyl synthase (EC number|2.8.1.8) is an enzyme that catalyzes the chemical reaction

:protein N₆-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine $ightleftharpoons$ protein N₆-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosine

The 3 substrates of this enzyme are protein N6-(octanoyl)lysine, sulfur, and S-adenosyl-L-methionine, whereas its 3 products are protein N6-(lipoyl)lysine, L-methionine, and 5'-deoxyadenosine.

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is protein N6-(octanoyl)lysine:sulfur sulfurtransferase. Other names in common use include LS, LipA, lipoate synthase, and protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase. This enzyme participates in lipoic acid metabolism.

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