(heparan sulfate)-glucosamine 3-sulfotransferase 1
- (heparan sulfate)-glucosamine 3-sulfotransferase 1
'In enzymology, a [heparan sulfate] -glucosamine 3-sulfotransferase 1"' (EC number|2.8.2.23) is an enzyme that catalyzes the chemical reaction
:3'-phosphoadenylyl sulfate + [heparan sulfate] -glucosamine ightleftharpoons adenosine 3',5'-bisphosphate + [heparan sulfate] -glucosamine 3-sulfate
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and [heparan sulfate-glucosamine] , whereas its two products are adenosine 3',5'-bisphosphate and [heparan sulfate-glucosamine 3-sulfate] .
This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate: [heparan sulfate] -glucosamine 3-sulfotransferase. Other names in common use include heparin-glucosamine 3-O-sulfotransferase, 3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase, glucosaminyl 3-O-sulfotransferase, heparan sulfate D-glucosaminyl 3-O-sulfotransferase, and isoform/isozyme 1 (3-OST-1, HS3ST1). This enzyme participates in heparan sulfate biosynthesis and glycan structures - biosynthesis 1.
tructural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1VKJ and PDB link|1ZRH.
References
*
*
*
*
*
*
External links
::"The CAS registry number for this enzyme class is CAS registry|118113-79-4."
Gene Ontology (GO) codes
Wikimedia Foundation.
2010.
Look at other dictionaries:
(heparan sulfate)-glucosamine N-sulfotransferase — In enzymology, a [heparan sulfate] glucosamine N sulfotransferase (EC number|2.8.2.8) is an enzyme that catalyzes the chemical reaction:3 phosphoadenylyl sulfate + [heparan sulfate] glucosamine ightleftharpoons adenosine 3 ,5 bisphosphate +… … Wikipedia
(heparan sulfate)-glucosamine 3-sulfotransferase 2 — In enzymology, a [heparan sulfate] glucosamine 3 sulfotransferase 2 (EC number|2.8.2.29) is an enzyme that catalyzes the chemical reaction:3 phosphoadenylyl sulfate + [heparan sulfate] glucosamine ightleftharpoons adenosine 3 ,5 bisphosphate +… … Wikipedia
(heparan sulfate)-glucosamine 3-sulfotransferase 3 — In enzymology, a [heparan sulfate] glucosamine 3 sulfotransferase 3 (EC number|2.8.2.30) is an enzyme that catalyzes the chemical reaction:3 phosphoadenylyl sulfate + [heparan sulfate] glucosamine ightleftharpoons adenosine 3 ,5 bisphosphate +… … Wikipedia
Heparan sulfate — (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan (PG) in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. [cite book | title=Proteoglycans:… … Wikipedia
List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… … Wikipedia
NDST1 — N deacetylase/N sulfotransferase (heparan glucosaminyl) 1 PDB rendering based on 1nst … Wikipedia
NDST2 — N deacetylase/N sulfotransferase (heparan glucosaminyl) 2 Identifiers Symbols NDST2; HSST2; MGC129697; MGC129705; NST2 External IDs … Wikipedia
NDST3 — N deacetylase/N sulfotransferase (heparan glucosaminyl) 3 Identifiers Symbols NDST3; HSST3; MGC130028; MGC130029 External IDs … Wikipedia
HS3ST3A1 — Heparan sulfate (glucosamine) 3 O sulfotransferase 3A1, also known as HS3ST3A1, is a human gene.cite web | title = Entrez Gene: HS3ST3A1 heparan sulfate (glucosamine) 3 O sulfotransferase 3A1| url =… … Wikipedia
HS3ST1 — Heparan sulfate (glucosamine) 3 O sulfotransferase 1, also known as HS3ST1, is a human gene.cite web | title = Entrez Gene: HS3ST1 heparan sulfate (glucosamine) 3 O sulfotransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… … Wikipedia