5-(carboxyamino)imidazole ribonucleotide mutase

5-(carboxyamino)imidazole ribonucleotide mutase
5-(carboxyamino)imidazole ribonucleotide mutase
Identifiers
EC number 5.4.99.18
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a 5-(carboxyamino)imidazole ribonucleotide mutase (EC 5.4.99.18) is an enzyme that catalyzes the chemical reaction

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole \rightleftharpoons 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

Hence, this enzyme has one substrate, 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole, and one product, 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase. Other names in common use include N5-CAIR mutase, PurE, N5-carboxyaminoimidazole ribonucleotide mutase, and class I PurE.

References

  • Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM (1992). "Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway". Biochemistry. 31 (21): 5022–32. doi:10.1021/bi00136a016. PMID 1534690. 
  • Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J (1994). "N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli". Biochemistry. 33 (8): 2269–78. doi:10.1021/bi00174a038. PMID 8117684. 
  • Meyer E, Kappock TJ, Osuji C, Stubbe J (1999). "Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase". Biochemistry. 38 (10): 3012–8. doi:10.1021/bi9827159. PMID 10074353. 
  • Mathews II, Kappock TJ, Stubbe J, Ealick SE (1999). "Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway". Structure. 7 (11): 1395–406. doi:10.1016/S0969-2126(00)80029-5. PMID 10574791. 
  • Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ (1994). "Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms". Biochemistry. 33 (39): 11927–34. doi:10.1021/bi00205a031. PMID 7918411. 
  • Davisson VJ; Misialek, S; Toffaletti, DL; Klem, TJ; Perfect, JR; Davisson, VJ (1998). "Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis". Arch. Biochem. Biophys. 351 (1): 123–34. doi:10.1006/abbi.1997.0512. PMID 9500840. 


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