5-carboxymethyl-2-hydroxymuconate Delta-isomerase

In enzymology, a 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (EC number|5.3.3.10) is an enzyme that catalyzes the chemical reaction

:5-carboxymethyl-2-hydroxymuconate $ightleftharpoons$ 5-carboxy-2-oxohept-3-enedioate

Hence, this enzyme has one substrate, 5-carboxymethyl-2-hydroxymuconate, and one product, 5-carboxy-2-oxohept-3-enedioate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is 5-carboxymethyl-2-hydroxymuconate Delta2,Delta4-2-oxo,Delta3-isomerase. This enzyme participates in tyrosine metabolism and benzoate degradation via hydroxylation.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GTT, PDB link|1I7O, PDB link|1WZO, and PDB link|2DFU.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|79079-05-3."

Gene Ontology (GO) codes