3-hydroxybutyryl-CoA epimerase

In enzymology, a 3-hydroxybutyryl-CoA epimerase (EC number|5.1.2.3) is an enzyme that catalyzes the chemical reaction

:(S)-3-hydroxybutanoyl-CoA $ightleftharpoons$ (R)-3-hydroxybutanoyl-CoA

Hence, this enzyme has one substrate, (S)-3-hydroxybutanoyl-CoA, and one product, (R)-3-hydroxybutanoyl-CoA.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on hydroxy acids and derivatives. The systematic name of this enzyme class is 3-hydroxybutanoyl-CoA 3-epimerase. Other names in common use include 3-hydroxybutyryl coenzyme A epimerase, and 3-hydroxyacyl-CoA epimerase. This enzyme participates in fatty acid metabolism and butanoate metabolism.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1WDK, PDB link|1WDL, PDB link|1WDM, and PDB link|2D3T.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9024-21-9."

Gene Ontology (GO) codes