PPP1CB

Protein phosphatase 1, catalytic subunit, beta isoform, also known as PPP1CB, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.cite web | title = Entrez Gene: PPP1CB protein phosphatase 1, catalytic subunit, beta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5500| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Prochazka M, Mochizuki H, Baier LJ, "et al." |title=Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians. |journal=Diabetologia |volume=38 |issue= 4 |pages= 461–6 |year= 1995 |pmid= 7796987 |doi=
*cite journal | author=Saadat M, Kakinoki Y, Mizuno Y, "et al." |title=Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization. |journal=Jpn. J. Genet. |volume=69 |issue= 6 |pages= 697–700 |year= 1995 |pmid= 7857673 |doi=
*cite journal | author=Barker HM, Brewis ND, Street AJ, "et al." |title=Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB). |journal=Biochim. Biophys. Acta |volume=1220 |issue= 2 |pages= 212–8 |year= 1994 |pmid= 8312365 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Kawabe T, Muslin AJ, Korsmeyer SJ |title=HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. |journal=Nature |volume=385 |issue= 6615 |pages= 454–8 |year= 1997 |pmid= 9009195 |doi= 10.1038/385454a0
*cite journal | author=Fujioka M, Takahashi N, Odai H, "et al." |title=A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping. |journal=Genomics |volume=49 |issue= 1 |pages= 59–68 |year= 1998 |pmid= 9570949 |doi= 10.1006/geno.1998.5222
*cite journal | author=Verin AD, Csortos C, Durbin SD, "et al." |title=Characterization of the protein phosphatase 1 catalytic subunit in endothelium: involvement in contractile responses. |journal=J. Cell. Biochem. |volume=79 |issue= 1 |pages= 113–25 |year= 2000 |pmid= 10906760 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Tan I, Ng CH, Lim L, Leung T |title=Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21209–16 |year= 2001 |pmid= 11399775 |doi= 10.1074/jbc.M102615200
*cite journal | author=Fresu M, Bianchi M, Parsons JT, Villa-Moruzzi E |title=Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase. |journal=Biochem. J. |volume=358 |issue= Pt 2 |pages= 407–14 |year= 2001 |pmid= 11513739 |doi=
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Bharucha DC, Zhou M, Nekhai S, "et al." |title=A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat. |journal=Virology |volume=296 |issue= 1 |pages= 6–16 |year= 2002 |pmid= 12036313 |doi= 10.1006/viro.2002.1438
*cite journal | author=Ceulemans H, Vulsteke V, De Maeyer M, "et al." |title=Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47331–7 |year= 2003 |pmid= 12226088 |doi= 10.1074/jbc.M206838200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Galey D, Becker K, Haughey N, "et al." |title=Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. |journal=J. Neurovirol. |volume=9 |issue= 3 |pages= 358–71 |year= 2003 |pmid= 12775419 |doi=
*cite journal | author=Ammosova T, Jerebtsova M, Beullens M, "et al." |title=Nuclear protein phosphatase-1 regulates HIV-1 transcription. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 32189–94 |year= 2003 |pmid= 12788939 |doi= 10.1074/jbc.M300521200
*cite journal | author=Llorian M, Beullens M, Andrés I, "et al." |title=SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. |journal=Biochem. J. |volume=378 |issue= Pt 1 |pages= 229–38 |year= 2004 |pmid= 14640981 |doi= 10.1042/BJ20030950
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086

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