PPP2R2A

Protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform, also known as PPP2R2A, is a human gene.

PBB_Summary
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summary_text = The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily.cite web | title = Entrez Gene: PPP2R2A protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5520| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. |journal=Biochem. Pharmacol. |volume=60 |issue= 8 |pages= 1225–35 |year= 2000 |pmid= 11007961 |doi=
*cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789
*cite journal | author=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43–51 |year= 2005 |pmid= 15638722 |doi=
*cite journal | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue= |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11
*cite journal | author=Kamibayashi C, Lickteig RL, Estes R, "et al." |title=Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits. |journal=J. Biol. Chem. |volume=267 |issue= 30 |pages= 21864–72 |year= 1992 |pmid= 1328247 |doi=
*cite journal | author=Mayer RE, Hendrix P, Cron P, "et al." |title=Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. |journal=Biochemistry |volume=30 |issue= 15 |pages= 3589–97 |year= 1991 |pmid= 1849734 |doi=
*cite journal | author=Tung HY, De Rocquigny H, Zhao LJ, "et al." |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 197–201 |year= 1997 |pmid= 9013886 |doi=
*cite journal | author=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. |journal=Virology |volume=238 |issue= 2 |pages= 432–43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873
*cite journal | author=Strack S, Zaucha JA, Ebner FF, "et al." |title=Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits. |journal=J. Comp. Neurol. |volume=392 |issue= 4 |pages= 515–27 |year= 1998 |pmid= 9514514 |doi=
*cite journal | author=Griswold-Prenner I, Kamibayashi C, Maruoka EM, "et al." |title=Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A. |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6595–604 |year= 1998 |pmid= 9774674 |doi=
*cite journal | author=Ruediger R, Fields K, Walter G |title=Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens. |journal=J. Virol. |volume=73 |issue= 1 |pages= 839–42 |year= 1999 |pmid= 9847399 |doi=
*cite journal | author=Kim ST, Lim DS, Canman CE, Kastan MB |title=Substrate specificities and identification of putative substrates of ATM kinase family members. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37538–43 |year= 2000 |pmid= 10608806 |doi=
*cite journal | author=Moreno CS, Park S, Nelson K, "et al." |title=WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5257–63 |year= 2000 |pmid= 10681496 |doi=
*cite journal | author=Husi H, Ward MA, Choudhary JS, "et al." |title=Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. |journal=Nat. Neurosci. |volume=3 |issue= 7 |pages= 661–9 |year= 2000 |pmid= 10862698 |doi= 10.1038/76615
*cite journal | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956–67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956
*cite journal | author=Vogelsberg-Ragaglia V, Schuck T, Trojanowski JQ, Lee VM |title=PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus. |journal=Exp. Neurol. |volume=168 |issue= 2 |pages= 402–12 |year= 2001 |pmid= 11259128 |doi= 10.1006/exnr.2001.7630
*cite journal | author=Elder RT, Yu M, Chen M, "et al." |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359–70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007
*cite journal | author=Bennin DA, Don AS, Brake T, "et al." |title=Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27449–67 |year= 2002 |pmid= 11956189 |doi= 10.1074/jbc.M111693200
*cite journal | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=21 |issue= 14 |pages= 3918 |year= 2002 |pmid= 12110603 |doi= 10.1093/emboj/cdf420

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