GPX4

Glutathione peroxidase 4 (phospholipid hydroperoxidase), also known as GPX4, is a human gene.

PBB_Summary
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summary_text = Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified.cite web | title = Entrez Gene: GPX4 glutathione peroxidase 4 (phospholipid hydroperoxidase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2879| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakagawa Y |title=Role of mitochondrial phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an antiapoptotic factor. |journal=Biol. Pharm. Bull. |volume=27 |issue= 7 |pages= 956–60 |year= 2005 |pmid= 15256721 |doi=
*cite journal | author=Esworthy RS, Doan K, Doroshow JH, Chu FF |title=Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase. |journal=Gene |volume=144 |issue= 2 |pages= 317–8 |year= 1994 |pmid= 8039723 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Chu FF |title=The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. |journal=Cytogenet. Cell Genet. |volume=66 |issue= 2 |pages= 96–8 |year= 1994 |pmid= 8287691 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Opalenik SR, Ding Q, Mallery SR, Thompson JA |title=Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor. |journal=Arch. Biochem. Biophys. |volume=351 |issue= 1 |pages= 17–26 |year= 1998 |pmid= 9501919 |doi= 10.1006/abbi.1997.0566
*cite journal | author=Kelner MJ, Montoya MA |title=Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3. |journal=Biochem. Biophys. Res. Commun. |volume=249 |issue= 1 |pages= 53–5 |year= 1998 |pmid= 9705830 |doi= 10.1006/bbrc.1998.9086
*cite journal | author=Ursini F, Heim S, Kiess M, "et al." |title=Dual function of the selenoprotein PHGPx during sperm maturation. |journal=Science |volume=285 |issue= 5432 |pages= 1393–6 |year= 1999 |pmid= 10464096 |doi=
*cite journal | author=Choi J, Liu RM, Kundu RK, "et al." |title=Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3693–8 |year= 2000 |pmid= 10652368 |doi=
*cite journal | author=Richard MJ, Guiraud P, Didier C, "et al." |title=Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation. |journal=Arch. Biochem. Biophys. |volume=386 |issue= 2 |pages= 213–20 |year= 2001 |pmid= 11368344 |doi= 10.1006/abbi.2000.2197
*cite journal | author=Yagi K, Komura S, Ohishi N |title=Expression of human phospholipid hydroperoxide glutathione peroxidase. |journal=Methods Mol. Biol. |volume=196 |issue= |pages= 195–9 |year= 2003 |pmid= 12152199 |doi= 10.1385/1-59259-274-0:195
*cite journal | author=Foresta C, Flohé L, Garolla A, "et al." |title=Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase. |journal=Biol. Reprod. |volume=67 |issue= 3 |pages= 967–71 |year= 2003 |pmid= 12193409 |doi=
*cite journal | author=Borchert A, Savaskan NE, Kuhn H |title=Regulation of expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Tissue-specific expression pattern and identification of functional cis- and trans-regulatory elements. |journal=J. Biol. Chem. |volume=278 |issue= 4 |pages= 2571–80 |year= 2003 |pmid= 12427732 |doi= 10.1074/jbc.M209064200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Villette S, Kyle JA, Brown KM, "et al." |title=A novel single nucleotide polymorphism in the 3' untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism. |journal=Blood Cells Mol. Dis. |volume=29 |issue= 2 |pages= 174–8 |year= 2003 |pmid= 12490284 |doi=
*cite journal | author=Maiorino M, Bosello V, Ursini F, "et al." |title=Genetic variations of gpx-4 and male infertility in humans. |journal=Biol. Reprod. |volume=68 |issue= 4 |pages= 1134–41 |year= 2004 |pmid= 12606444 |doi= 10.1095/biolreprod.102.007500
*cite journal | author=Wang HP, Schafer FQ, Goswami PC, "et al." |title=Phospholipid hydroperoxide glutathione peroxidase induces a delay in G1 of the cell cycle. |journal=Free Radic. Res. |volume=37 |issue= 6 |pages= 621–30 |year= 2003 |pmid= 12868489 |doi=
*cite journal | author=Chen CJ, Huang HS, Chang WC |title=Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells. |journal=FASEB J. |volume=17 |issue= 12 |pages= 1694–6 |year= 2003 |pmid= 12958179 |doi= 10.1096/fj.02-0847fje
*cite journal | author=Sneddon AA, Wu HC, Farquharson A, "et al." |title=Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants. |journal=Atherosclerosis |volume=171 |issue= 1 |pages= 57–65 |year= 2004 |pmid= 14642406 |doi=

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