(R)-6-hydroxynicotine oxidase

In enzymology, a (R)-6-hydroxynicotine oxidase (EC number|1.5.3.6) is an enzyme that catalyzes the chemical reaction

:(R)-6-hydroxynicotine + H₂O + O₂ $ightleftharpoons$ 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H₂O₂

The 3 substrates of this enzyme are (R)-6-hydroxynicotine, H₂O, and O₂, whereas its two products are 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is (R)-6-hydroxynicotine:oxygen oxidoreductase. Other names in common use include D-6-hydroxynicotine oxidase, and 6-hydroxy-D-nicotine oxidase. It employs one cofactor, FAD.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2BVF, PDB link|2BVG, and PDB link|2BVH.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37233-46-8."

Gene Ontology (GO) codes