Methylenetetrahydromethanopterin dehydrogenase

methylenetetrahydromethanopterin dehydrogenase
Identifiers
EC number	1.5.99.9
CAS number	100357-01-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a methylenetetrahydromethanopterin dehydrogenase (EC 1.5.99.9) is an enzyme that catalyzes the chemical reaction

5,10-methylenetetrahydromethanopterin + coenzyme F₄20 $\rightleftharpoons$ 5,10-methenyltetrahydromethanopterin + reduced coenzyme F₄20

Thus, the two substrates of this enzyme are 5,10-methylenetetrahydromethanopterin and coenzyme F420, whereas its two products are 5,10-methenyltetrahydromethanopterin and reduced coenzyme F420.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is 5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase. Other names in common use include N5,N10-methylenetetrahydromethanopterin dehydrogenase, and 5,10-methylenetetrahydromethanopterin dehydrogenase. This enzyme participates in folate biosynthesis.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1QV9, 1U6I, 1U6J, and 1U6K.

References

• Hartzell PL, Zvilius G, Escalante-Semerena JC, Donnelly MI (1985). "Coenzyme F420 dependence of the methylenetetrahydromethanopterin dehydrogenase of Methanobacterium thermoautotrophicum". Biochem. Biophys. Res. Commun. 133 (3): 884–90. doi:10.1016/0006-291X(85)91218-5. PMID 4084309. 
• GD; Geerts, WJ; Keltjens, JT; Van Der Drift, C; Vogels, GD (1991). "Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri". Biochim. Biophys. Acta. 1079 (3): 293–302. doi:10.1016/0167-4838(91)90072-8. PMID 1911853. 

This EC 1.5 enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Oxidoreductase stubs EC 1.5.99 Enzymes of known structure Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? The co-operative food 2007–08 Speed Skating World Cup Look at other dictionaries: F420 — Strukturformel Allgemeines Name F420 Andere Namen Coenzym F420 …   Deutsch Wikipedia List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia Coenzyme F420 — Structure of Coenzyme F420 Coenzyme F420 or 8 hydroxy 5 deazaflavin is a coenzyme involved in redox reactions in methanogens [1], in many Actinobacteria, and sporadically in other bacterial lineages. It is a flavin derivative. The coenzyme is a… …   Wikipedia Кофермент F420 — (Coenzyme F420) или 8 гидрокси 5 деазофлавин  это кофермент, участвующий в восстановительных реакциях у продуцентов метана,[1] например, у Methanosarcina barkeri. Это производное флавина. Данный кофермент является субстратом для гидрогеназы… …   Википедия Coenzyme F420 — Structure de la coenzyme F420. Général No CAS …   Wikipédia en Français Méthylènetétrahydrométhanoptérine déshydrogénase —   N° EC   EC …   Wikipédia en Français Méthylènetétrahydrométhanoptérine réductase —   N° EC   EC …   Wikipédia en Français Hydrogenase — A hydrogenase is an enzyme that catalyses the reversible oxidation of molecular hydrogen (H2). Hydrogenases play a vital role in anaerobic metabolism. [cite journal | author=Adams, M.W.W. and Stiefel, E.I. | title=Biological hydrogen production:… …   Wikipedia Hydrogenase — Hydrogénase Les hydrogénases sont des enzymes qui catalysent de façon réversible la conversion des protons en dihydrogène selon la réaction : 2H+ + 2 e = H2 Il existe deux grandes classes d hydrogénases : les hydrogénases [NiFe] et les… …   Wikipédia en Français Hydrogénase — Les hydrogénases sont des enzymes qui catalysent de façon réversible la conversion des ions H+ (« protons ») en dihydrogène selon la réaction : 2H+ + 2 e = H2 Les sites actifs de ces enzymes sont de nature organométallique et… …   Wikipédia en Français 18+ © Academic, 2000-2025 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”