FCER1A

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a human gene.

PBB_Summary
section_title =
summary_text = The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated. [supplied by OMIM] cite web | title = Entrez Gene: FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2205| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gounni AS |title=The high-affinity IgE receptor (FcepsilonRI): a critical regulator of airway smooth muscle cells? |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=291 |issue= 3 |pages= L312–21 |year= 2006 |pmid= 16581830 |doi= 10.1152/ajplung.00005.2006
*cite journal | author=Padlan EA, Helm BA |title=A modeling study of the alpha-subunit of human high-affinity receptor for immunoglobulin-E. |journal=Receptor |volume=2 |issue= 2 |pages= 129–44 |year= 1993 |pmid= 1472946 |doi=
*cite journal | author=Wang B, Rieger A, Kilgus O, "et al." |title=Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI. |journal=J. Exp. Med. |volume=175 |issue= 5 |pages= 1353–65 |year= 1992 |pmid= 1533243 |doi=
*cite journal | author=Küster H, Zhang L, Brini AT, "et al." |title=The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor. |journal=J. Biol. Chem. |volume=267 |issue= 18 |pages= 12782–7 |year= 1992 |pmid= 1535625 |doi=
*cite journal | author=Le Coniat M, Kinet JP, Berger R |title=The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23. |journal=Immunogenetics |volume=32 |issue= 3 |pages= 183–6 |year= 1990 |pmid= 2146219 |doi=
*cite journal | author=Shimizu A, Tepler I, Benfey PN, "et al." |title=Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 6 |pages= 1907–11 |year= 1988 |pmid= 2964640 |doi=
*cite journal | author=Kochan J, Pettine LF, Hakimi J, "et al." |title=Isolation of the gene coding for the alpha subunit of the human high affinity IgE receptor. |journal=Nucleic Acids Res. |volume=16 |issue= 8 |pages= 3584 |year= 1988 |pmid= 2967464 |doi=
*cite journal | author=Yagi S, Yanagida M, Tanida I, "et al." |title=High-level expression of the truncated alpha chain of human high-affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product. |journal=Eur. J. Biochem. |volume=220 |issue= 2 |pages= 593–8 |year= 1994 |pmid= 8125119 |doi=
*cite journal | author=Pang J, Taylor GR, Munroe DG, "et al." |title=Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. |journal=J. Immunol. |volume=151 |issue= 11 |pages= 6166–74 |year= 1994 |pmid= 8245459 |doi=
*cite journal | author=Walsh MT, Divane A, Whitehead AS |title=Fine mapping of the human pentraxin gene region on chromosome 1q23. |journal=Immunogenetics |volume=44 |issue= 1 |pages= 62–9 |year= 1996 |pmid= 8613143 |doi=
*cite journal | author=Maurer D, Fiebiger S, Ebner C, "et al." |title=Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. |journal=J. Immunol. |volume=157 |issue= 2 |pages= 607–16 |year= 1996 |pmid= 8752908 |doi=
*cite journal | author=Garman SC, Wurzburg BA, Tarchevskaya SS, "et al." |title=Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha. |journal=Nature |volume=406 |issue= 6793 |pages= 259–66 |year= 2000 |pmid= 10917520 |doi= 10.1038/35018500
*cite journal | author=Nishiyama C, Hasegawa M, Nishiyama M, "et al." |title=Cloning of full-length genomic DNA encoding human FcepsilonRI alpha-chain and its transcriptional regulation. |journal=Biochem. Biophys. Res. Commun. |volume=284 |issue= 4 |pages= 1056–64 |year= 2001 |pmid= 11409901 |doi= 10.1006/bbrc.2001.5079
*cite journal | author=Garman SC, Sechi S, Kinet JP, Jardetzky TS |title=The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. |journal=J. Mol. Biol. |volume=311 |issue= 5 |pages= 1049–62 |year= 2001 |pmid= 11531339 |doi= 10.1006/jmbi.2001.4929
*cite journal | author=Shikanai T, Silverman ES, Morse BW, "et al." |title=Sequence variants in the FcepsilonRI alpha chain gene. |journal=J. Appl. Physiol. |volume=93 |issue= 1 |pages= 37–41 |year= 2002 |pmid= 12070183 |doi= 10.1152/japplphysiol.00993.2001
*cite journal | author=Sada K, Miah SM, Maeno K, "et al." |title=Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. |journal=Blood |volume=100 |issue= 6 |pages= 2138–44 |year= 2002 |pmid= 12200378 |doi= 10.1182/blood-2001-12-0340
*cite journal | author=Takahashi K, Nishiyama C, Ra C |title=Transcriptional regulation of the human high affinity IgE receptor alpha-chain gene. |journal=Mol. Immunol. |volume=38 |issue= 16-18 |pages= 1193–9 |year= 2003 |pmid= 12217383 |doi=
*cite journal | author=Vangelista L, Cesco-Gaspere M, Lamba D, Burrone O |title=Efficient folding of the FcepsilonRI alpha-chain membrane-proximal domain D2 depends on the presence of the N-terminal domain D1. |journal=J. Mol. Biol. |volume=322 |issue= 4 |pages= 815–25 |year= 2002 |pmid= 12270716 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hasegawa M, Nishiyama C, Nishiyama M, "et al." |title=Regulation of the human Fc epsilon RI alpha-chain distal promoter. |journal=J. Immunol. |volume=170 |issue= 7 |pages= 3732–8 |year= 2003 |pmid= 12646639 |doi=

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