6,7-dihydropteridine reductase

In enzymology, a 6,7-dihydropteridine reductase (EC number|1.5.1.34) is an enzyme that catalyzes the chemical reaction

:a 5,6,7,8-tetrahydropteridine + NAD(P)+ $ightleftharpoons$ a 6,7-dihydropteridine + NAD(P)H + H⁺

The 3 substrates of this enzyme are 5,6,7,8-tetrahydropteridine, NAD⁺, and NADP⁺, whereas its 4 products are 6,7-dihydropteridine, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase. Other names in common use include 6,7-dihydropteridine:NAD(P)H oxidoreductase, DHPR, NAD(P)H:6,7-dihydropteridine oxidoreductase, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide), reductase, dihydropteridine reductase, dihydropteridine reductase (NADH), and 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase. This enzyme participates in folate biosynthesis.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1YKI, PDB link|1YLR, and PDB link|1YLU.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9074-11-7."

Gene Ontology (GO) codes