Quercetin 2,3-dioxygenase

In enzymology, a quercetin 2,3-dioxygenase (EC number|1.13.11.24) is an enzyme that catalyzes the chemical reaction

:quercetin + O₂ $ightleftharpoons$ 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H⁺

Thus, the two substrates of this enzyme are quercetin and O₂, whereas its 3 products are 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate, CO, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is quercetin:oxygen 2,3-oxidoreductase (decyclizing). Other names in common use include quercetinase, and flavonol 2,4-oxygenase. It has 2 cofactors: iron, and Copper.

tructural studies

As of late 2007, 6 crystal structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GQG, PDB link|1GQH, PDB link|1H1I, PDB link|1H1M, PDB link|1JUH, and PDB link|2H0V.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9075-67-6."

Gene Ontology (GO) codes