Hydroxyquinol 1,2-dioxygenase

In enzymology, a hydroxyquinol 1,2-dioxygenase (EC number|1.13.11.37) is an enzyme that catalyzes the chemical reaction

:benzene-1,2,4-triol + O₂ $ightleftharpoons$ 3-hydroxy-cis,cis-muconate

Thus, the two substrates of this enzyme are benzene-1,2,4-triol and O₂, whereas its product is 3-hydroxy-cis,cis-muconate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing). This enzyme is also called hydroxyquinol dioxygenase. This enzyme participates in benzoate degradation via hydroxylation and 1,4-dichlorobenzene degradation. It employs one cofactor, iron.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1TMX.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|91847-14-2."

Gene Ontology (GO) codes