Acireductone dioxygenase (Ni2+-requiring)

In enzymology, an acireductone dioxygenase (Ni2+-requiring) (EC number|1.13.11.53) is an enzyme that catalyzes the chemical reaction

:1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O₂ $ightleftharpoons$ 3-(methylthio)propanoate + formate + CO

Thus, the two substrates of this enzyme are 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one and O₂, whereas its 3 products are 3-(methylthio)propanoate, formate, and CO.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming). Other names in common use include ARD, 2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase (ambiguous), acireductone dioxygenase (ambiguous), and E-2. This enzyme participates in methionine metabolism.

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External links

Gene Ontology (GO) codes