Aquacobalamin reductase (NADPH)

In enzymology, an aquacobalamin reductase (NADPH) (EC number|1.16.1.5) is an enzyme that catalyzes the chemical reaction

:2 cob(II)alamin + NADP⁺ $ightleftharpoons$ 2 aquacob(III)alamin + NADPH + H⁺

Thus, the two substrates of this enzyme are cob(II)alamin and NADP⁺, whereas its 3 products are aquacob(III)alamin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cob(II)alamin:NADP+ oxidoreductase. Other names in common use include aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate), reductase, NADPH-linked aquacobalamin reductase, and NADPH2:aquacob(III)alamin oxidoreductase. This enzyme participates in porphyrin and chlorophyll metabolism. It employs one cofactor, FAD.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|110777-32-7."

Gene Ontology (GO) codes