GPX1

Glutathione peroxidase 1, also known as GPX1, is a human gene.

PBB_Summary
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summary_text = This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. It has been reported that the protein encoded by this gene protects from CD95-induced apoptosis in cultured breast cancer cells and inhibits 5-lipoxygenase in blood cells, and its overexpression delays endothelial cell growth and increases resistance to toxic challenges. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.cite web | title = Entrez Gene: GPX1 glutathione peroxidase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2876| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Moscow JA, Morrow CS, He R, "et al." |title=Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1). |journal=J. Biol. Chem. |volume=267 |issue= 9 |pages= 5949–58 |year= 1992 |pmid= 1556108 |doi=
*cite journal | author=Chada S, Le Beau MM, Casey L, Newburger PE |title=Isolation and chromosomal localization of the human glutathione peroxidase gene. |journal=Genomics |volume=6 |issue= 2 |pages= 268–71 |year= 1990 |pmid= 2307470 |doi=
*cite journal | author=Mullenbach GT, Tabrizi A, Irvine BD, "et al." |title=Sequence of a cDNA coding for human glutathione peroxidase confirms TGA encodes active site selenocysteine. |journal=Nucleic Acids Res. |volume=15 |issue= 13 |pages= 5484 |year= 1987 |pmid= 2955287 |doi=
*cite journal | author=Mullenbach GT, Tabrizi A, Irvine BD, "et al." |title=Selenocysteine's mechanism of incorporation and evolution revealed in cDNAs of three glutathione peroxidases. |journal=Protein Eng. |volume=2 |issue= 3 |pages= 239–46 |year= 1989 |pmid= 2976939 |doi=
*cite journal | author=Sukenaga Y, Ishida K, Takeda T, Takagi K |title=cDNA sequence coding for human glutathione peroxidase. |journal=Nucleic Acids Res. |volume=15 |issue= 17 |pages= 7178 |year= 1987 |pmid= 3658677 |doi=
*cite journal | author=Ishida K, Morino T, Takagi K, Sukenaga Y |title=Nucleotide sequence of a human gene for glutathione peroxidase. |journal=Nucleic Acids Res. |volume=15 |issue= 23 |pages= 10051 |year= 1988 |pmid= 3697069 |doi=
*cite journal | author=Moscow JA, Schmidt L, Ingram DT, "et al." |title=Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer. |journal=Carcinogenesis |volume=15 |issue= 12 |pages= 2769–73 |year= 1995 |pmid= 8001233 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Chu FF, Doroshow JH, Esworthy RS |title=Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2571–6 |year= 1993 |pmid= 8428933 |doi=
*cite journal | author=Esworthy RS, Ho YS, Chu FF |title=The Gpx1 gene encodes mitochondrial glutathione peroxidase in the mouse liver. |journal=Arch. Biochem. Biophys. |volume=340 |issue= 1 |pages= 59–63 |year= 1997 |pmid= 9126277 |doi= 10.1006/abbi.1997.9901
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Opalenik SR, Ding Q, Mallery SR, Thompson JA |title=Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor. |journal=Arch. Biochem. Biophys. |volume=351 |issue= 1 |pages= 17–26 |year= 1998 |pmid= 9501919 |doi= 10.1006/abbi.1997.0566
*cite journal | author=Kiss C, Li J, Szeles A, "et al." |title=Assignment of the ARHA and GPX1 genes to human chromosome bands 3p21.3 by in situ hybridization and with somatic cell hybrids. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3-4 |pages= 228–30 |year= 1998 |pmid= 9605859 |doi=
*cite journal | author=Forsberg L, de Faire U, Morgenstern R |title=Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1. |journal=Hum. Mutat. |volume=13 |issue= 4 |pages= 294–300 |year= 1999 |pmid= 10220143 |doi= 10.1002/(SICI)1098-1004(1999)13:4<294::AID-HUMU6>3.0.CO;2-5 |doilabel=10.1002/(SICI)1098-1004(1999)13:4294::AID-HUMU63.0.CO;2-5
*cite journal | author=Choi J, Liu RM, Kundu RK, "et al." |title=Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3693–8 |year= 2000 |pmid= 10652368 |doi=
*cite journal | author=Legault J, Carrier C, Petrov P, "et al." |title=Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 2 |pages= 416–22 |year= 2000 |pmid= 10833429 |doi= 10.1006/bbrc.2000.2800
*cite journal | author=Straif D, Werz O, Kellner R, "et al." |title=Glutathione peroxidase-1 but not -4 is involved in the regulation of cellular 5-lipoxygenase activity in monocytic cells. |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 455–61 |year= 2001 |pmid= 10880344 |doi=
*cite journal | author=Richard MJ, Guiraud P, Didier C, "et al." |title=Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation. |journal=Arch. Biochem. Biophys. |volume=386 |issue= 2 |pages= 213–20 |year= 2001 |pmid= 11368344 |doi= 10.1006/abbi.2000.2197
*cite journal | author=Ishibashi N, Prokopenko O, Reuhl KR, Mirochnitchenko O |title=Inflammatory response and glutathione peroxidase in a model of stroke. |journal=J. Immunol. |volume=168 |issue= 4 |pages= 1926–33 |year= 2002 |pmid= 11823528 |doi=
*cite journal | author=Gouaze V, Andrieu-Abadie N, Cuvillier O, "et al." |title=Glutathione peroxidase-1 protects from CD95-induced apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42867–74 |year= 2003 |pmid= 12221075 |doi= 10.1074/jbc.M203067200

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