APOA4

Apolipoprotein A-IV, also known as APOA4, is a human gene.

PBB_Summary
section_title =
summary_text = Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro.cite web | title = Entrez Gene: APOA4 apolipoprotein A-IV| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=337| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=von Eckardstein A, Funke H, Schulte M, "et al." |title=Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population. |journal=Am. J. Hum. Genet. |volume=50 |issue= 5 |pages= 1115–28 |year= 1992 |pmid= 1349197 |doi=
*cite journal | author=Kamboh MI, Williams ER, Law JC, "et al." |title=Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism. |journal=Genet. Epidemiol. |volume=9 |issue= 6 |pages= 379–88 |year= 1993 |pmid= 1487136 |doi= 10.1002/gepi.1370090602
*cite journal | author=Lohse P, Kindt MR, Rader DJ, Brewer HB |title=Three genetic variants of human plasma apolipoprotein A-IV. apoA-IV-1(Thr347----Ser), apoA-IV-0(Lys167----Glu,Gln360----His), and apoA-IV-3(Glu165----Lys). |journal=J. Biol. Chem. |volume=266 |issue= 21 |pages= 13513–8 |year= 1991 |pmid= 1677358 |doi=
*cite journal | author=Tenkanen H, Koskinen P, Metso J, "et al." |title=A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127. |journal=Biochim. Biophys. Acta |volume=1138 |issue= 1 |pages= 27–33 |year= 1992 |pmid= 1737067 |doi=
*cite journal | author=Lohse P, Kindt MR, Rader DJ, Brewer HB |title=Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1. |journal=J. Biol. Chem. |volume=265 |issue= 21 |pages= 12734–9 |year= 1990 |pmid= 1973689 |doi=
*cite journal | author=Tenkanen H, Lukka M, Jauhiainen M, "et al." |title=The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360. |journal=Arterioscler. Thromb. |volume=11 |issue= 4 |pages= 851–6 |year= 1991 |pmid= 2065039 |doi=
*cite journal | author=de Temmerman P, Visvikis S, Boerwinkle E, Siest G |title=Study of the sequence tagged site (STS) in the beginning of human apo A4 gene region. |journal=Nucleic Acids Res. |volume=18 |issue= 18 |pages= 5576 |year= 1990 |pmid= 2216752 |doi=
*cite journal | author=Wei S, Rocchi M, Archidiacono N, "et al." |title=Physical mapping of the human chromosome 11q23 region containing the ataxia-telangiectasia locus. |journal=Cancer Genet. Cytogenet. |volume=46 |issue= 1 |pages= 1–8 |year= 1990 |pmid= 2331673 |doi=
*cite journal | author=Lohse P, Kindt MR, Rader DJ, Brewer HB |title=Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene. |journal=J. Biol. Chem. |volume=265 |issue= 17 |pages= 10061–4 |year= 1990 |pmid= 2351649 |doi=
*cite journal | author=Yang CY, Gu ZW, Chong IS, "et al." |title=The primary structure of human apolipoprotein A-IV. |journal=Biochim. Biophys. Acta |volume=1002 |issue= 2 |pages= 231–7 |year= 1989 |pmid= 2930771 |doi=
*cite journal | author=Elshourbagy NA, Walker DW, Paik YK, "et al." |title=Structure and expression of the human apolipoprotein A-IV gene. |journal=J. Biol. Chem. |volume=262 |issue= 17 |pages= 7973–81 |year= 1987 |pmid= 3036793 |doi=
*cite journal | author=Elshourbagy NA, Walker DW, Boguski MS, "et al." |title=The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III. |journal=J. Biol. Chem. |volume=261 |issue= 5 |pages= 1998–2002 |year= 1986 |pmid= 3080432 |doi=
*cite journal | author=Karathanasis SK, Oettgen P, Haddad IA, Antonarakis SE |title=Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 22 |pages= 8457–61 |year= 1986 |pmid= 3095836 |doi=
*cite journal | author=Bisgaier CL, Sachdev OP, Lee ES, "et al." |title=Effect of lecithin:cholesterol acyltransferase on distribution of apolipoprotein A-IV among lipoproteins of human plasma. |journal=J. Lipid Res. |volume=28 |issue= 6 |pages= 693–703 |year= 1987 |pmid= 3611972 |doi=
*cite journal | author=Karathanasis SK, Yunis I, Zannis VI |title=Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV. |journal=Biochemistry |volume=25 |issue= 13 |pages= 3962–70 |year= 1986 |pmid= 3755616 |doi=
*cite journal | author=Karathanasis SK |title=Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 19 |pages= 6374–8 |year= 1985 |pmid= 3931073 |doi=
*cite journal | author=Gordon JI, Bisgaier CL, Sims HF, "et al." |title=Biosynthesis of human preapolipoprotein A-IV. |journal=J. Biol. Chem. |volume=259 |issue= 1 |pages= 468–74 |year= 1984 |pmid= 6706947 |doi=
*cite journal | author=Menzel HJ, Dieplinger H, Sandholzer C, "et al." |title=Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants. |journal=Hum. Mutat. |volume=5 |issue= 1 |pages= 58–65 |year= 1995 |pmid= 7728150 |doi= 10.1002/humu.1380050108
*cite journal | author=Duverger N, Tremp G, Caillaud JM, "et al." |title=Protection against atherogenesis in mice mediated by human apolipoprotein A-IV. |journal=Science |volume=273 |issue= 5277 |pages= 966–8 |year= 1996 |pmid= 8688083 |doi=
*cite journal | author=Deeb SS, Nevin DN, Iwasaki L, Brunzell JD |title=Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity. |journal=Hum. Mutat. |volume=8 |issue= 4 |pages= 319–25 |year= 1997 |pmid= 8956036 |doi= 10.1002/(SICI)1098-1004(1996)8:4<319::AID-HUMU4>3.0.CO;2-2

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