2-oxoaldehyde dehydrogenase (NAD+)

In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) (EC number|1.2.1.23) is an enzyme that catalyzes the chemical reaction

:a 2-oxoaldehyde + NAD⁺ + H₂O $ightleftharpoons$ a 2-oxo acid + NADH + H⁺

The 3 substrates of this enzyme are 2-oxoaldehyde, NAD⁺, and H₂O, whereas its 3 products are 2-oxo acid, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NAD+ 2-oxidoreductase. Other names in common use include alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NAD+-linked alpha-ketoaldehyde dehydrogenase, 2-ketoaldehyde dehydrogenase, NAD+-dependent alpha-ketoaldehyde dehydrogenase, and 2-oxoaldehyde dehydrogenase (NAD+). This enzyme participates in pyruvate metabolism.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37250-91-2."

Gene Ontology (GO) codes