Galactose oxidase

In enzymology, a galactose oxidase (EC number|1.1.3.9) is an enzyme that catalyzes the chemical reaction

:D-galactose + O₂ $ightleftharpoons$ D-galacto-hexodialdose + H₂O₂

Thus, the two substrates of this enzyme are D-galactose and O₂, whereas its two products are D-galacto-hexodialdose and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is D-galactose:oxygen 6-oxidoreductase. Other names in common use include D-galactose oxidase, and beta-galactose oxidase. This enzyme participates in galactose metabolism. It employs two cofactors, copper and an active site amino acid derived post-translational modification involving the covalent cross-linking of Cys228 and Tyr272 and which represents the site of the catalytic free radical.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GOF, PDB link|1GOG, PDB link|1GOH, PDB link|1K3I, PDB link|1T2X, PDB link|2EIB, PDB link|2EIC, PDB link|2EID, and PDB link|2EIE.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-79-9."

Gene Ontology (GO) codes