PPP1CA

Protein phosphatase 1, catalytic subunit, alpha isoform, also known as PPP1CA, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [cite web | title = Entrez Gene: PPP1CA protein phosphatase 1, catalytic subunit, alpha isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5499| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cohen PT |title=Protein phosphatase 1--targeted in many directions. |journal=J. Cell. Sci. |volume=115 |issue= Pt 2 |pages= 241–56 |year= 2002 |pmid= 11839776 |doi=
*cite journal | author=Barker HM, Jones TA, da Cruz e Silva EF, "et al." |title=Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13. |journal=Genomics |volume=7 |issue= 2 |pages= 159–66 |year= 1990 |pmid= 2161401 |doi=
*cite journal | author=Carrey EA, Campbell DG, Hardie DG |title=Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis. |journal=EMBO J. |volume=4 |issue= 13B |pages= 3735–42 |year= 1986 |pmid= 4092695 |doi=
*cite journal | author=Saadat M, Mizuno Y, Kikuchi K, Yoshida MC |title=Comparative mapping of the gene encoding the catalytic subunit of protein phosphatase type 1 alpha (PPP1CA) to human, rat, and mouse chromosomes. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 1-2 |pages= 55–7 |year= 1995 |pmid= 7736790 |doi=
*cite journal | author=Durfee T, Becherer K, Chen PL, "et al." |title=The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. |journal=Genes Dev. |volume=7 |issue= 4 |pages= 555–69 |year= 1993 |pmid= 8384581 |doi=
*cite journal | author=Song Q, Khanna KK, Lu H, Lavin MF |title=Cloning and characterization of a human protein phosphatase 1-encoding cDNA. |journal=Gene |volume=129 |issue= 2 |pages= 291–5 |year= 1993 |pmid= 8392016 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Kwon YG, Huang HB, Desdouits F, "et al." |title=Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 8 |pages= 3536–41 |year= 1997 |pmid= 9108011 |doi=
*cite journal | author=Colbran RJ, Bass MA, McNeill RB, "et al." |title=Association of brain protein phosphatase 1 with cytoskeletal targeting/regulatory subunits. |journal=J. Neurochem. |volume=69 |issue= 3 |pages= 920–9 |year= 1997 |pmid= 9282913 |doi=
*cite journal | author=Allen PB, Kwon YG, Nairn AC, Greengard P |title=Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit. |journal=J. Biol. Chem. |volume=273 |issue= 7 |pages= 4089–95 |year= 1998 |pmid= 9461602 |doi=
*cite journal | author=Zhang J, Zhang L, Zhao S, Lee EY |title=Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1. |journal=Biochemistry |volume=37 |issue= 47 |pages= 16728–34 |year= 1998 |pmid= 9843442 |doi= 10.1021/bi981169g
*cite journal | author=Neumann J, Maas R, Bokník P, "et al." |title=Pharmacological characterization of protein phosphatase activities in preparations from failing human hearts. |journal=J. Pharmacol. Exp. Ther. |volume=289 |issue= 1 |pages= 188–93 |year= 1999 |pmid= 10087003 |doi=
*cite journal | author=Schillace RV, Scott JD |title=Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220. |journal=Curr. Biol. |volume=9 |issue= 6 |pages= 321–4 |year= 1999 |pmid= 10209101 |doi=
*cite journal | author=Takahashi M, Shibata H, Shimakawa M, "et al." |title=Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 17267–74 |year= 1999 |pmid= 10358086 |doi=
*cite journal | author=McAvoy T, Allen PB, Obaishi H, "et al." |title=Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation. |journal=Biochemistry |volume=38 |issue= 39 |pages= 12943–9 |year= 1999 |pmid= 10504266 |doi=
*cite journal | author=Yoshida K, Watanabe M, Kato H, "et al." |title=BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain. |journal=FEBS Lett. |volume=460 |issue= 1 |pages= 93–8 |year= 1999 |pmid= 10571067 |doi=
*cite journal | author=Yang J, Hurley TD, DePaoli-Roach AA |title=Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22635–44 |year= 2000 |pmid= 10807923 |doi= 10.1074/jbc.M003082200
*cite journal | author=Ayllón V, Martínez-A C, García A, "et al." |title=Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis. |journal=EMBO J. |volume=19 |issue= 10 |pages= 2237–46 |year= 2000 |pmid= 10811615 |doi= 10.1093/emboj/19.10.2237
*cite journal | author=Boudrez A, Beullens M, Groenen P, "et al." |title=NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25411–7 |year= 2000 |pmid= 10827081 |doi= 10.1074/jbc.M001676200
*cite journal | author=Helps NR, Luo X, Barker HM, Cohen PT |title=NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1. |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 509–18 |year= 2001 |pmid= 10880350 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes