KPNA1

Karyopherin alpha 1 (importin alpha 5), also known as KPNA1, is a human gene.

PBB_Summary
section_title =
summary_text = Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in V(D)J recombination [cite web | title = Entrez Gene: KPNA1 karyopherin alpha 1 (importin alpha 5)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3836| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: in search of a leader. |journal=Front. Biosci. |volume=2 |issue= |pages= d578–87 |year= 2004 |pmid= 9366553 |doi=
*cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. |journal=Mol. Med. |volume=4 |issue= 3 |pages= 138–43 |year= 1998 |pmid= 9562972 |doi=
*cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789
*cite journal | author=Bukrinsky MI, Sharova N, Dempsey MP, "et al." |title=Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 14 |pages= 6580–4 |year= 1992 |pmid= 1631159 |doi=
*cite journal | author=Sharova N, Bukrinskaya A |title=p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells. |journal=AIDS Res. Hum. Retroviruses |volume=7 |issue= 3 |pages= 303–6 |year= 1991 |pmid= 2064827 |doi=
*cite journal | author=Di Marzio P, Choe S, Ebright M, "et al." |title=Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. |journal=J. Virol. |volume=69 |issue= 12 |pages= 7909–16 |year= 1996 |pmid= 7494303 |doi=
*cite journal | author=Gallay P, Swingler S, Song J, "et al." |title=HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. |journal=Cell |volume=83 |issue= 4 |pages= 569–76 |year= 1995 |pmid= 7585960 |doi=
*cite journal | author=Moroianu J, Hijikata M, Blobel G, Radu A |title=Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 14 |pages= 6532–6 |year= 1995 |pmid= 7604027 |doi=
*cite journal | author=Freed EO, Englund G, Martin MA |title=Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection. |journal=J. Virol. |volume=69 |issue= 6 |pages= 3949–54 |year= 1995 |pmid= 7745752 |doi=
*cite journal | author=Weis K, Mattaj IW, Lamond AI |title=Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. |journal=Science |volume=268 |issue= 5213 |pages= 1049–53 |year= 1995 |pmid= 7754385 |doi=
*cite journal | author=O'Neill RE, Palese P |title=NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein. |journal=Virology |volume=206 |issue= 1 |pages= 116–25 |year= 1995 |pmid= 7831767 |doi=
*cite journal | author=Gallay P, Swingler S, Aiken C, Trono D |title=HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. |journal=Cell |volume=80 |issue= 3 |pages= 379–88 |year= 1995 |pmid= 7859280 |doi=
*cite journal | author=Moroianu J, Blobel G, Radu A |title=Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 6 |pages= 2008–11 |year= 1995 |pmid= 7892216 |doi=
*cite journal | author=von Schwedler U, Kornbluth RS, Trono D |title=The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 6992–6 |year= 1994 |pmid= 8041734 |doi=
*cite journal | author=Heinzinger NK, Bukinsky MI, Haggerty SA, "et al." |title=The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 7311–5 |year= 1994 |pmid= 8041786 |doi=
*cite journal | author=Cortes P, Ye ZS, Baltimore D |title=RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 16 |pages= 7633–7 |year= 1994 |pmid= 8052633 |doi=
*cite journal | author=Bukrinsky MI, Haggerty S, Dempsey MP, "et al." |title=A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. |journal=Nature |volume=365 |issue= 6447 |pages= 666–9 |year= 1993 |pmid= 8105392 |doi= 10.1038/365666a0
*cite journal | author=Dubrovsky L, Ulrich P, Nuovo GJ, "et al." |title=Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. |journal=Mol. Med. |volume=1 |issue= 2 |pages= 217–30 |year= 1996 |pmid= 8529100 |doi=
*cite journal | author=Gallay P, Stitt V, Mundy C, "et al." |title=Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. |journal=J. Virol. |volume=70 |issue= 2 |pages= 1027–32 |year= 1996 |pmid= 8551560 |doi=
*cite journal | author=Bukrinskaya AG, Ghorpade A, Heinzinger NK, "et al." |title=Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 367–71 |year= 1996 |pmid= 8552640 |doi=

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