- Importin
Importin is a type of
protein that moves other protein molecules into the nucleus by binding to a specific recognition sequence, called thenuclear localization signal (NLS). Importin is classified as akaryopherin . [http://big.mcw.edu/display.php/1053.html] cite journal | author = Görlich D, Prehn S, Laskey RA, Hartmann E | title = Isolation of a protein that is essential for the first step of nuclear protein import | journal = Cell | volume = 79 | issue = 5 | pages = 767–78 | year = 1994 | pmid = 8001116 | doi = 10.1016/0092-8674(94)90067-1 | issn = ]Importin has two subunits, importin α and importin β. Of these, importin α binds to the NLS of the protein to be imported to the nucleus whereas importin β helps in the docking of the importin
heterodimer -bound protein to thenuclear pore complex . The NLS-Importin α-Importin β trimer dissociates after binding to Ran GTP inside the nucleus.cite journal | author = Mattaj IW, Englmeier L | title = Nucleocytoplasmic transport: the soluble phase | journal = Annu. Rev. Biochem. | volume = 67 | issue = | pages = 265–306 | year = 1998 | pmid = 9759490 | doi = 10.1146/annurev.biochem.67.1.265 | issn = ]Genes
* Importin: Gene|IPO4,
IPO7 , Gene|IPO8,IPO9 , Gene|IPO11, Gene|IPO13
* Karyopherin-α:KPNA1 ,KPNA2 ,KPNA3 ,KPNA4 ,KPNA5 ,KPNA6
* Karyopherin-β:KPNB1 References
External links
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