TIMP1

TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a human gene.

PBB_Summary
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summary_text = This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [cite web | title = Entrez Gene: TIMP1 TIMP metallopeptidase inhibitor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7076| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hornebeck W |title=Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival. |journal=Pathol. Biol. |volume=51 |issue= 10 |pages= 569–73 |year= 2004 |pmid= 14622947 |doi=
*cite journal | author=Gardner J, Ghorpade A |title=Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system. |journal=J. Neurosci. Res. |volume=74 |issue= 6 |pages= 801–6 |year= 2004 |pmid= 14648584 |doi= 10.1002/jnr.10835

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