- (S)-canadine synthase
In
enzymology , a (S)-canadine synthase (EC number|1.14.21.5) is anenzyme that catalyzes thechemical reaction :(S)-tetrahydrocolumbamine + NADPH + H+ + O2 (S)-canadine + NADP+ + 2 H2O
The 4 substrates of this enzyme are
(S)-tetrahydrocolumbamine , NADPH, H+, and O2, whereas its 3 products are(S)-canadine , NADP+, and H2O.This enzyme belongs to the family of
oxidoreductase s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and the other dehydrogenated. The systematic name of this enzyme class is (S)-tetrahydrocolumbamine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming). Other names in common use include (S)-tetrahydroberberine synthase, and (S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming). This enzyme participates inalkaloid biosynthesis i . It employs one cofactor,heme-thiolate(P-450) .References
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External links
::"The
CAS registry number for this enzyme class is CAS registry|114308-22-4."Gene Ontology (GO) codes
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