Peptide-aspartate beta-dioxygenase
- Peptide-aspartate beta-dioxygenase
In enzymology, a peptide-aspartate beta-dioxygenase (EC number|1.14.11.16) is an enzyme that catalyzes the chemical reaction
:peptide-L-aspartate + 2-oxoglutarate + O2 peptide-3-hydroxy-L-aspartate + succinate + CO2
The 3 substrates of this enzyme are peptide-L-aspartate, 2-oxoglutarate, and O2, whereas its 3 products are peptide-3-hydroxy-L-aspartate, succinate, and CO2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating). Other names in common use include aspartate beta-hydroxylase, and aspartylpeptide beta-dioxygenase. It employs one cofactor, iron.
tructural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1YCI, PDB link|2CGN, PDB link|2CGO, and PDB link|2ILM.
References
*
External links
::"The CAS registry number for this enzyme class is CAS registry|122544-66-5."
Gene Ontology (GO) codes
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