- Cholesterol monooxygenase (side-chain-cleaving)
In
enzymology , a cholesterol monooxygenase (side-chain-cleaving) (EC number|1.14.15.6) is anenzyme that catalyzes thechemical reaction :cholesterol + reduced adrenal ferredoxin + O2 pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O
The 3 substrates of this enzyme are
cholesterol ,reduced adrenal ferredoxin , and O2, whereas its 4 products arepregnenolone ,4-methylpentanal ,oxidized adrenal ferredoxin , and H2O.This enzyme belongs to the family of
oxidoreductase s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced iron-sulfur protein as one donor, and incorporation o one atom of oxygen into the other donor. The systematic name of this enzyme class is cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving). Other names in common use include cholesterol desmolase, cytochrome P-450scc, desmolase, steroid 20-22, C27-side chain cleavage enzyme, cholesterol 20-22-desmolase, cholesterol C20-22 desmolase, cholesterol side-chain cleavage enzyme, cholesterol side-chain-cleaving enzyme, enzymes, cholesterol side-chain-cleaving, steroid 20-22 desmolase, and steroid 20-22-lyase. This enzyme participates inc21-steroid hormone metabolism . It employs one cofactor,heme .References
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*External links
::"The
CAS registry number for this enzyme class is CAS registry|37292-81-2."Gene Ontology (GO) codes
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