- 3-hydroxy-2-methylpyridinecarboxylate dioxygenase
In
enzymology , a 3-hydroxy-2-methylpyridinecarboxylate dioxygenase (EC number|1.14.12.4) is anenzyme that catalyzes thechemical reaction :3-hydroxy-2-methylpyridine-5-carboxylate + NAD(P)H + H+ + O2 2-(acetamidomethylene)succinate + NAD(P)+
The 5 substrates of this enzyme are
3-hydroxy-2-methylpyridine-5-carboxylate , NADH, NADPH, H+, and O2, whereas its 3 products are2-(acetamidomethylene)succinate , NAD+, and NADP+.This enzyme belongs to the family of
oxidoreductase s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of two atoms o oxygen into the other donor. The systematic name of this enzyme class is 3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (decyclizing). Other names in common use include methylhydroxypyridinecarboxylate oxidase, 2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase, methylhydroxypyridine carboxylate dioxygenase, and 3-hydroxy-3-methylpyridinecarboxylate dioxygenase [incorrect] . This enzyme participates invitamin b6 metabolism . It employs one cofactor,FAD .References
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External links
::"The
CAS registry number for this enzyme class is CAS registry|37256-69-2."Gene Ontology (GO) codes
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