12-oxophytodienoate reductase

In enzymology, a 12-oxophytodienoate reductase (EC number|1.3.1.42) is an enzyme that catalyzes the chemical reaction

:8- [(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl] octanoate + NADP⁺ $ightleftharpoons$ (15Z)-12-oxophyto-10,15-dienoate + NADPH + H⁺

Thus, the two substrates of this enzyme are [8- [(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl] octanoate] and NADP⁺, whereas its 3 products are (15Z)-12-oxophyto-10,15-dienoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 8- [(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl] octanoate:NADP+ 4-oxidoreductase. This enzyme is also called 12-oxo-phytodienoic acid reductase.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1ICP, PDB link|1ICQ, PDB link|1ICS, PDB link|1Q45, PDB link|2G5W, PDB link|2HS6, PDB link|2HS8, PDB link|2HSA, PDB link|2Q3O, and PDB link|2Q3R.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|101150-03-2."

Gene Ontology (GO) codes