Glutathione S-transferase Mu 1

Glutathione S-transferase Mu 1 (gene name GSTM1) is a human glutathione S-transferase.

PBB_Summary
section_title =
summary_text = Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [cite web | title = Entrez Gene: GSTM1 glutathione S-transferase M1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2944| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Engel LS, Taioli E, Pfeiffer R, "et al." |title=Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review. |journal=Am. J. Epidemiol. |volume=156 |issue= 2 |pages= 95–109 |year= 2002 |pmid= 12117698 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes