RRNA (adenine-N6-)-methyltransferase

In enzymology, a rRNA (adenine-N6-)-methyltransferase (EC number|2.1.1.48) is an enzyme that catalyzes the chemical reaction

:S-adenosyl-L-methionine + rRNA $ightleftharpoons$ S-adenosyl-L-homocysteine + rRNA containing N₆-methyladenine

Thus, the two substrates of this enzyme are S-adenosyl methionine and rRNA, whereas its two products are S-adenosylhomocysteine and rRNA containing N6-methyladenine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase. Other names in common use include ribosomal ribonucleate adenine 6-methyltransferase, gene ksgA methyltransferase, ribonucleic acid-adenine (N6) methylase, ErmC 23S rRNA methyltransferase, and S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1QAM, PDB link|1QAN, PDB link|1QAO, PDB link|1QAQ, PDB link|1YUB, and PDB link|2ERC.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9076-81-7."

Gene Ontology (GO) codes