Methylated-DNA-(protein)-cysteine S-methyltransferase

In enzymology, a methylated-DNA- [protein] -cysteine S-methyltransferase (EC number|2.1.1.63) is an enzyme that catalyzes the chemical reaction

:DNA (containing 6-O-methylguanine) + protein L-cysteine $ightleftharpoons$ DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine

Thus, the two substrates of this enzyme are DNA containing 6-O-methylguanine and protein L-cysteine, whereas its two products are DNA and protein S-methyl-L-cysteine. The S-methyl-L-cysteine residue irreversibly inactivates the protein, allowing only one transfer for each protein.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is DNA-6-O-methylguanine: [protein] -L-cysteine S-methyltransferase.

tructural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1EH6, PDB link|1EH7, PDB link|1EH8, PDB link|1MGT, PDB link|1QNT, PDB link|1SFE, PDB link|1T38, PDB link|1T39, PDB link|1WRJ, PDB link|1YFH, and PDB link|2G7H.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|77271-19-3."

Gene Ontology (GO) codes