Glycine N-methyltransferase

In enzymology, a glycine N-methyltransferase (EC number|2.1.1.20) is an enzyme that catalyzes the chemical reaction

:S-adenosyl-L-methionine + glycine $ightleftharpoons$ S-adenosyl-L-homocysteine + sarcosine

Thus, the two substrates of this enzyme are S-adenosyl methionine and glycine, whereas its two products are S-adenosylhomocysteine and sarcosine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:glycine N-methyltransferase. Other names in common use include glycine methyltransferase, S-adenosyl-L-methionine:glycine methyltransferase, and GNMT. This enzyme participates in glycine, serine and threonine metabolism.

tructural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1BHJ, PDB link|1D2C, PDB link|1D2G, PDB link|1D2H, PDB link|1KIA, PDB link|1NBH, PDB link|1NBI, PDB link|1R74, PDB link|1XVA, PDB link|2AZT, PDB link|2IDJ, and PDB link|2IDK.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37228-72-1."

Gene Ontology (GO) codes