5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase

In enzymology, a 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC number|2.1.1.14) is an enzyme that catalyzes the chemical reaction

:5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine $ightleftharpoons$ tetrahydropteroyltri-L-glutamate + L-methionine

Thus, the two substrates of this enzyme are 5-methyltetrahydropteroyltri-L-glutamatic acid and L-homocysteine, whereas its two products are tetrahydropteroyltri-L-glutamatic acid and L-methionine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is 5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase. Other names in common use include tetrahydropteroyltriglutamate methyltransferase, homocysteine methylase, methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase, methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase, cobalamin-independent methionine synthase, methionine synthase (cobalamin-independent), and MetE. This enzyme participates in methionine metabolism. It has 2 cofactors: orthophosphate, and zinc.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1T7L, PDB link|1U1H, PDB link|1U1J, PDB link|1U1U, PDB link|1U22, PDB link|1XDJ, PDB link|1XPG, PDB link|1XR2, and PDB link|2NQ5.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9068-29-5."

Gene Ontology (GO) codes