3beta-hydroxy-5alpha-steroid dehydrogenase

3beta-hydroxy-5alpha-steroid dehydrogenase

In enzymology, a 3beta-hydroxy-5alpha-steroid dehydrogenase (EC number|1.1.1.278) is an enzyme that catalyzes the chemical reaction

:3beta-hydroxy-5alpha-pregnane-20-one + NADP+ ightleftharpoons 5alpha-pregnan-3,20-dione + NADPH + H+

Thus, the two substrates of this enzyme are 3beta-hydroxy-5alpha-pregnane-20-one and NADP+, whereas its 3 products are 5alpha-pregnan-3,20-dione, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase.

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