2,5-didehydrogluconate reductase

In enzymology, a 2,5-didehydrogluconate reductase (EC number|1.1.1.274) is an enzyme that catalyzes the chemical reaction

:2-dehydro-D-gluconate + NADP⁺ $ightleftharpoons$ 2,5-didehydro-D-gluconate + NADPH + H⁺

Thus, the two substrates of this enzyme are 2-dehydro-D-gluconate and NADP⁺, whereas its 3 products are 2,5-didehydro-D-gluconate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-dehydro-D-gluconate:NADP+ 2-oxidoreductase. Other names in common use include 2,5-diketo-D-gluconate reductase, and YqhE reductase.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1VP5.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|95725-95-4."

Gene Ontology (GO) codes