15-hydroxyprostaglandin dehydrogenase (NAD+)
- 15-hydroxyprostaglandin dehydrogenase (NAD+)
In enzymology, a 15-hydroxyprostaglandin dehydrogenase (NAD+) (EC number|1.1.1.141) is an enzyme that catalyzes the chemical reaction
:(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+
Thus, the two substrates of this enzyme are (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate and NAD+, whereas its 3 products are (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase. Other names in common use include NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I), PGDH, 11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase, 15-OH-PGDH, 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostanoic dehydrogenase, NAD+-specific 15-hydroxyprostaglandin dehydrogenase, prostaglandin dehydrogenase, and 15-hydroxyprostaglandin dehydrogenase (NAD+).
tructural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|2GDZ.
References
*
*
*
*
External links
::"The CAS registry number for this enzyme class is CAS registry|9030-87-9."
Gene Ontology (GO) codes
Wikimedia Foundation.
2010.
Look at other dictionaries:
15-hydroxyprostaglandin dehydrogenase — may refer to: * 15 hydroxyprostaglandin D dehydrogenase (NADP+) * 15 hydroxyprostaglandin I dehydrogenase (NADP+) * 15 hydroxyprostaglandin dehydrogenase (NAD+) * 15 hydroxyprostaglandin dehydrogenase (NADP+) … Wikipedia
15-hydroxyprostaglandin dehydrogenase (NADP+) — In enzymology, a 15 hydroxyprostaglandin dehydrogenase (NADP+) (EC number|1.1.1.197) is an enzyme that catalyzes the chemical reaction:(13E) (15S) 11alpha,15 dihydroxy 9 oxoprost 13 enoate + NADP+ ightleftharpoons (13E) 11alpha hydroxy 9,15… … Wikipedia
15-hydroxyprostaglandin dehydrogenase — An enzyme that catalyzes the oxidation of prostaglandins, rendering them inactive, by converting the 15 hydroxyl group to a keto group using NAD+ … Medical dictionary
15-hydroxyprostaglandin-D dehydrogenase (NADP+) — In enzymology, a 15 hydroxyprostaglandin D dehydrogenase (NADP+) (EC number|1.1.1.196) is an enzyme that catalyzes the chemical reaction:(5Z,13E) (15S) 9alpha,15 dihydroxy 11 oxoprosta 5,13 dienoate + NADP+ ightleftharpoons (5Z,13E) 9alpha… … Wikipedia
15-hydroxyprostaglandin-I dehydrogenase (NADP+) — In enzymology, a 15 hydroxyprostaglandin I dehydrogenase (NADP+) (EC number|1.1.1.231) is an enzyme that catalyzes the chemical reaction:(5Z,13E) (15S) 6,9alpha epoxy 11alpha,15 dihydroxyprosta 5,13 dienoate + NADP+ ightleftharpoons (5Z,13E)… … Wikipedia
3alpha-hydroxysteroid dehydrogenase (B-specific) — In enzymology, a 3alpha hydroxysteroid dehydrogenase (B specific) (EC number|1.1.1.50) is an enzyme that catalyzes the chemical reaction:androsterone + NAD(P)+ ightleftharpoons 5alpha androstane 3,17 dione + NAD(P)H + H+The 3 substrates of this… … Wikipedia
List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH … Wikipedia
ABCC4 — ATP binding cassette, sub family C (CFTR/MRP), member 4 Identifiers Symbols ABCC4; EST170205; MOAT B; MOATB; MRP4 External IDs … Wikipedia
HPGD — Hydroxyprostaglandin dehydrogenase 15 (NAD), also known as HPGD, is a human gene.cite web | title = Entrez Gene: HPGD hydroxyprostaglandin dehydrogenase 15 (NAD)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… … Wikipedia
