15-hydroxyicosatetraenoate dehydrogenase

In enzymology, a 15-hydroxyicosatetraenoate dehydrogenase (EC number|1.1.1.232) is an enzyme that catalyzes the chemical reaction

:(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)+ $ightleftharpoons$ 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate, NAD⁺, and NADP⁺, whereas its 4 products are 15-oxo-5,8,11-cis-13-trans-icosatetraenoate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase. This enzyme is also called 15-hydroxyeicosatetraenoate dehydrogenase. This enzyme participates in arachidonic acid metabolism.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|117910-46-0."

Gene Ontology (GO) codes