UDP-N-acetylmuramate dehydrogenase

In enzymology, an UDP-N-acetylmuramate dehydrogenase (EC number|1.1.1.158) is an enzyme that catalyzes the chemical reaction

:UDP-N-acetylmuramate + NADP⁺ $ightleftharpoons$ UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H⁺

Thus, the two substrates of this enzyme are UDP-N-acetylmuramate and NADP⁺, whereas its 3 products are UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is UDP-N-acetylmuramate:NADP+ oxidoreductase. Other names in common use include MurB reductase, UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylglucosamine-enoylpyruvate reductase, UDP-GlcNAc-enoylpyruvate reductase, uridine diphosphoacetylpyruvoylglucosamine reductase, uridine diphospho-N-acetylglucosamine-enolpyruvate reductase, uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-, and lactylglucose:NADP-oxidoreductase. This enzyme participates in aminosugars metabolism. It employs one cofactor, FAD.

tructural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1HSK, PDB link|1MBB, PDB link|1MBT, PDB link|1UXY, PDB link|2GQT, PDB link|2GQU, PDB link|2MBR, and PDB link|2Q85.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|39307-28-3."

Gene Ontology (GO) codes