Tetrahydroxynaphthalene reductase

In enzymology, a tetrahydroxynaphthalene reductase (EC number|1.1.1.252) is an enzyme that catalyzes the chemical reaction

:scytalone + NADP⁺ $ightleftharpoons$ 1,3,6,8-tetrahydroxynaphthalene + NADPH + H⁺

Thus, the two substrates of this enzyme are scytalone and NADP⁺, whereas its 3 products are 1,3,6,8-tetrahydroxynaphthalene, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is scytalone:NADP+ Delta5-oxidoreductase.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DOH, PDB link|1G0N, and PDB link|1G0O.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|153702-05-7."

Gene Ontology (GO) codes