Lactaldehyde reductase

In enzymology, a lactaldehyde reductase (EC number|1.1.1.77) is an enzyme that catalyzes the chemical reaction

:(R) [or (S)] -propane-1,2-diol + NAD⁺ $ightleftharpoons$ (R) [or (S)] -lactaldehyde + NADH + H⁺

The 3 substrates of this enzyme are (R)-propane-1,2-diol, (S)-propane-1,2-diol, and NAD⁺, whereas its 4 products are (R)-lactaldehyde, (S)-lactaldehyde, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R) [or (S)] -propane-1,2-diol:NAD+ oxidoreductase. Other names in common use include propanediol:nicotinamide adenine dinucleotide (NAD+) oxidoreductase, and L-lactaldehyde:propanediol oxidoreductase. This enzyme participates in pyruvate metabolism and glyoxylate and dicarboxylate metabolism.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1RRM, PDB link|2BI4, and PDB link|2BL4.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37250-15-0."

Gene Ontology (GO) codes