4-hydroxythreonine-4-phosphate dehydrogenase

In enzymology, a 4-hydroxythreonine-4-phosphate dehydrogenase (EC number|1.1.1.262) is an enzyme that catalyzes the chemical reaction

:4-phosphonooxy-L-threonine + NAD⁺ $ightleftharpoons$ (2S)-2-amino-3-oxo-4-phosphonooxybutanoate + NADH + H⁺

Thus, the two substrates of this enzyme are 4-phosphonooxy-L-threonine and NAD⁺, whereas its 3 products are (2S)-2-amino-3-oxo-4-phosphonooxybutanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-phosphonooxy-L-threonine:NAD+ oxidoreductase. Other names in common use include NAD+-dependent threonine 4-phosphate dehydrogenase, L-threonine 4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase, PdxA, and 4-(phosphonooxy)-L-threonine:NAD+ oxidoreductase. This enzyme participates in vitamin b6 metabolism.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1PS6, PDB link|1PS7, PDB link|1PTM, PDB link|1R8K, PDB link|1YXO, and PDB link|2HI1.

References

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External links

Gene Ontology (GO) codes