Diiodophenylpyruvate reductase

Diiodophenylpyruvate reductase
diiodophenylpyruvate reductase
Identifiers
EC number 1.1.1.96
CAS number 37250-31-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a diiodophenylpyruvate reductase (EC 1.1.1.96) is an enzyme that catalyzes the chemical reaction

3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ \rightleftharpoons 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH + H+

Thus, the two substrates of this enzyme are 3-(3,5-diiodo-4-hydroxyphenyl)lactate and NAD+, whereas its 3 products are 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase. Other names in common use include aromatic alpha-keto acid, KAR, and 2-oxo acid reductase.

References

  • Zannoni VG, Weber WW (1966). "Isolation and properties of aromatic alpha-keto acid reductase". J. Biol. Chem. 241 (6): 1340–4. PMID 5935348. 
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