Small Nucleolar RNA SNORD94

Small Nucleolar RNA SNORD94 (also known as U94) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

SNOR94 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [1] . SNORD94 is predicted to guide the 2'O-ribose methylation of C62 of the snRNA U6 [2] .

References

* [1] cite journal |author= Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I; |title= Purified box C/D snoRNPs are able to reproduce site-specific2'-O-methylation of target RNA in vitro. |journal= Mol Cell Biol |volume= 22 |issue= |pages= 6663–6668 |year= 2002 |pmid=12215523 |doi= 10.1128/MCB.22.19.6663-6668.2002
* [2] cite journal |author= Vitali P, Royo H, Seitz H, Bachellerie JP, Huttenhofer A, Cavaille J; |title=Identification of 13 novel human modification guide RNAs. |journal= Nucleic Acids Res |volume= 31 |issue= |pages= 6543–6551 |year= 2003 |pmid=14602913 |doi=10.1093/nar/gkg849
* [3] cite journal |author= Lestrade L, Weber MJ; |title= snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D boxsnoRNAs. |journal= Nucleic Acids Res |volume= 34 |issue= |pages= D158–D162 |year= 2006 |pmid=16381836 |doi= 10.1093/nar/gkj002

External links

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* [http://www-snorna.biotoul.fr/plus.php?id=U94 snoRNABase entry for SNORD94 ]