Small Nucleolar RNA SNORD98

Small Nucleolar RNA SNORD98 (also known as HBII-419) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

SNORD98 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [1] . SNORD98 is predicted to guide the 2'0-ribose methylation of 18S ribosomal RNA (rRNA) residue G867 [3] .

References

* [1] cite journal |author= Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I; |title= Purified box C/D snoRNPs are able to reproduce site-specific2'-O-methylation of target RNA in vitro. |journal= Mol Cell Biol |volume= 22 |issue= |pages= 6663–6668 |year= 2002 |pmid=12215523 |doi= 10.1128/MCB.22.19.6663-6668.2002
* [2] cite journal |author= Huttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H,Bachellerie JP, Brosius J; |title= RNomics: an experimental approach that identifies 201 candidates fornovel, small, non-messenger RNAs in mouse. |journal= EMBO J |volume= 20 |issue= |pages= 2943–2953 |year= 2001 |pmid=11387227 |doi= 10.1093/emboj/20.11.2943
* [3] cite journal |author= Lestrade L, Weber MJ; |title= snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D boxsnoRNAs. |journal= Nucleic Acids Res |volume= 34 |issue= |pages= D158–D162 |year= 2006 |pmid=16381836 |doi= 10.1093/nar/gkj002

External links

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* [http://www-snorna.biotoul.fr/plus.php?id=HBII-419 snoRNABase entry for SNORD98]