- Mammalian CPEB3 ribozyme
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Mammalian CPEB3 ribozyme 
Predicted secondary structure and sequence conservation of CPEB3_ribozyme Identifiers Symbol CPEB3_ribozyme Rfam RF00622 Other data RNA type Gene; ribozyme Domain(s) Eukaryota SO 0000374 The mammalian CPEB3 ribozyme is a self cleaving non-coding RNA located in the second intron of the CPEB3 gene which belongs to a family of genes regulating messenger RNA polyadenylation.[1] This ribozyme is highly conserved and found only in mammals.[1] The CPEB3 ribozyme is structurally and biochemically related to the human hepatitis delta virus ribozyme.[2] Other HDV-like ribozymes have been identified and confirmed to be active in vitro in a number of eukaryotes.[3]
References
- ^ a b Salehi-Ashtiani K, Luptak A, Litovchick A, Szostak JW; (2006). "A genomewide search for ribozymes reveals an HDV-like sequence in thehuman CPEB3 gene.". Science 313 (5794): 1788–1792. doi:10.1126/science.1129308. PMID 16990549.
- ^ Chadalavada DM, Gratton EA, Bevilacqua PC (2010). "The Human HDV-like CPEB3 Ribozyme Is Intrinsically Fast-Reacting.". Biochemistry 49 (25): 5321–30. doi:10.1021/bi100434c. PMC 2890282. PMID 20524672. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2890282.
- ^ Webb, CH; Riccitelli, NJ, Ruminski, DJ, Lupták, A (2009 Nov 13). "Widespread occurrence of self-cleaving ribozymes.". Science (New York, N.Y.) 326 (5955): 953. PMID 19965505.
External links
Categories:- Molecular and cellular biology stubs
- Non-coding RNA
- Ribozymes
- RNA splicing
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