Wartenbergs migratory sensory neuropathy

Wartenberg's Migratory Sensory Neuropathy (also known as Wartenberg's Migrant Sensory Neuritis) (WMSN) is a rare condition identified by Robert Wartenberg in 1958 which is easy to confuse with the early stages of Multiple Sclerosis or Guillain-Barré syndrome. However this is a benign relapsing and remitting condition in which pain and subsequent loss of sensation in the distribution of individual cutaneous nerves is induced by movement of the limbs inducing stretch ^{[http://jnnp.bmj.com/cgi/content/abstract/46/1/1]} The movements may be very small, and the periods of pain, dysaesthesia, and numbness can vary from almost instantaneous to chronic. In some cases, reports discount WMSN as a diagnosis where there is less prominent pain [http://www.elsevier-international.com/e-books/viewbook.cfm?ID=942]

Only a few case studies have ever been reported [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=10975730&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus] , and even of Wartenbergs own patients only 2 of the 9 conform strictly to his own description of the clinical characteristics; however there are a couple of surprising case clusters of this condition in both the Thames Valley and San Francisco [http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1549075&blobtype=pdf]

Cause

Whilst the actual cause of this polyneuropathy remains unknown, most reasearch now puts this as an immune-mediated, chronic, asymmetric polyneuropathy [http://www.avondalemedical.com/pdf_files/PNMar2005/PN0305FeaNeuropathy.pdf] [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=11353434&query_hl=338] . Stress may also be a contributory factor.

Symptoms

Positive Tinel's sign is often present [http://scilib.univ.kiev.ua/article.php?16048337] . Any cutaneous sensory nerve can be involved with patients usually showing a slow start, building up to senasations in many parts of the body [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=1297555&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum] . At times, the focal nerve lesions can be painful. Most symptoms resolve but permanent sensory loss can persist. Electrodiagnostic studies demonstrate axon loss in the distribution of the involved cutaneous nerves [http://www.avondalemedical.com/pdf_files/PNMar2005/PN0305FeaNeuropathy.pdf] . Patients sometimes described a sensation of electric discharge when elongating nerve trunks. In half of the cases the attacks of dysesthesia or of sensory loss followed one another within less than one year. The deficits were fully reversible in a third of the cases studied by Rev Neurol (Pariis) after a mean total evolution of 4 to 8 years. [http://scilib.univ.kiev.ua/article.php?16048337]

Mean onset age, 35 years with a range of 4th and 5th decades [http://128.252.151.78/neuromuscular/nanatomy/asymmetric.html#wartenberg]

Pure sensory mononeuritis multiplex

Course: Episodic; RecurrentSome sensory loss improves, Other is permanent

Sensory loss:Discrete areas: Involvement of individual cutaneous nervesSudden onsetDistribution: Legs; Arms; Trunk; Face

Pain:In areas of sensory lossPainful dysesthesias: Induced by limb stretch or movement

Electrodiagnostic: Multifocal axon lossPathology: Biopsy of affected nervePerineurial scarringChronic inflammationAxonal loss & regeneration: Differential fascicular involvementEndoneurial edemaImmunoglobulin deposition

Treatments

Due to the unknown cause of this condition, treatment seems to be symptomatic and individual to the patient. Steroid treatments such as prednisone dont seem to work [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11353434&query_hl=11&itool=pubmed_docsum] but there is anecdotal evidence for the use of amitriptylene, and either pregabalin or gabapentin [http://www.partialobserver.com/Wartenberg.cfm#id35] along with a variety of painkilllers. This is often treated similarly to diabetic neuropathic pain, but diabetes is not necessarily present.

Some sufferers have responded well to the drug lyrica.Fact|date=May 2008