TRPA1

Transient receptor potential cation channel, subfamily A, member 1, also known as TRPA1, is a human gene.

PBB_Summary
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summary_text = The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [cite web | title = Entrez Gene: TRPA1 transient receptor potential cation channel, subfamily A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8989| accessdate = ]

Recent studies indicate that TRPA1 is activated by a number reactive compounds (allyl isothiocyanate, cinnamaldehyde, farnesyl thiosalicylic acid, formalin, hydrogen peroxide, 4-hydroxynonenal, and acrolein) and considered as a 'chemosensor' in the body. [cite journal |author=Tai C, Zhu S, Zhou N |title=TRPA1: the central molecule for chemical sensing in pain pathway? |journal=J. Neurosci. |volume=28 |issue=5 |pages=1019–21 |year=2008 |month=January |pmid=18234879 |doi=10.1523/JNEUROSCI.5237-07.2008] TRPA1 is considered as an attractive target pain based on the fact that TRPA1 knockout mice showed near complete attenuation of formalin-induced pain behaviors. [cite journal |author=McNamara CR, Mandel-Brehm J, Bautista DM, "et al" |title=TRPA1 mediates formalin-induced pain |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue=33 |pages=13525–30 |year=2007 |month=August |pmid=17686976 |pmc=1941642 |doi=10.1073/pnas.0705924104] [cite journal |author=McMahon SB, Wood JN |title=Increasingly irritable and close to tears: TRPA1 in inflammatory pain |journal=Cell |volume=124 |issue=6 |pages=1123–5 |year=2006 |month=March |pmid=16564004 |doi=10.1016/j.cell.2006.03.006] TRPA1 antagonists are effective in blocking pain behaviors induced by inflammation (complete Freund's adjuvant and formalin)

Although it is not firmly confirmed whether noxious cold sensation is mediated by TRPA1 in vivo, several recent studies clearly demonstrated cold activation of TRPA1 channels in vitro. [cite journal |author=Sawada Y, Hosokawa H, Hori A, Matsumura K, Kobayashi S |title=Cold sensitivity of recombinant TRPA1 channels |journal=Brain Res. |volume=1160 |issue= |pages=39–46 |year=2007 |month=July |pmid=17588549 |doi=10.1016/j.brainres.2007.05.047] [cite journal |author=Klionsky L, Tamir R, Gao B, "et al" |title=Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists |journal=Mol Pain |volume=3 |issue= |pages=39 |year=2007 |pmid=18086308 |pmc=2222611 |doi=10.1186/1744-8069-3-39]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Clapham DE, Julius D, Montell C, Schultz G |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 427–50 |year= 2006 |pmid= 16382100 |doi= 10.1124/pr.57.4.6
*cite journal | author=García-Añoveros J, Nagata K |title=TRPA1. |journal=Handb Exp Pharmacol |volume= |issue= 179 |pages= 347–62 |year= 2007 |pmid= 17217068 |doi= 10.1007/978-3-540-34891-7_21

External links

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