Lonafarnib

Lonafarnib

Chembox new
ImageFile=Lonafarnib.pngImageSize=200px
IUPACName=4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxamide
OtherNames=
Section1= Chembox Identifiers
CASNo=
PubChem=148195
SMILES=C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C (C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N

Section2= Chembox Properties
Formula=C27H31Br2ClN4O2
MolarMass=638.82164
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=

Section3= Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

Lonafarnib is a farnesyltransferase inhibitor.cite journal |author=Liu G, Marrinan CH, Taylor SA, "et al" |title=Enhancement of the antitumor activity of tamoxifen and anastrozole by the farnesyltransferase inhibitor lonafarnib (SCH66336) |journal=Anticancer Drugs |volume=18 |issue=8 |pages=923–31 |year=2007 |pmid=17667598 |doi=10.1097/CAD.0b013e3280c1416e]

References

ee also

* Laminopathy


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • lonafarnib — noun A particular farnesyl OH transferase inhibitor …   Wiktionary

  • lonafarnib — An anticancer drug that belongs to the family of drugs called enzyme inhibitors. Also called SCH 66336 …   English dictionary of cancer terms

  • Progeria — Infobox Disease Name = Progeria Caption = DiseasesDB = 10704 ICD10 = ICD10|E|34|8|e|20 ICD9 = ICD9|259.8 ICDO = OMIM = 176670 MedlinePlus = eMedicineSubj = derm eMedicineTopic = 731 MeshID = D011371 Progeria is a condition of early aging [Stedman …   Wikipedia

  • Farnesyltransferase inhibitor — The farnesyltransferase inhibitors (FTIs) are a class of experimental cancer drugs that target protein farnesyltransferase with the downstream effect of preventing the proper functioning of the Ras (protein), which is commonly abnormally active… …   Wikipedia

  • Prenylation — or isoprenylation or lipidation is the addition of hydrophobic molecules to a protein. It is usually assumed that prenyl groups facilitate attachment to cell membranes, similar to lipid anchor like the GPI anchor, though direct evidence is… …   Wikipedia

  • List of oncology-related terms — This is a list of terms related to oncology. The original source for this list was the U.S. National Cancer Institute s public domain Dictionary of Cancer Terms . NOTOC 1 * 10 propargyl 10 deazaaminopterin * 12 O tetradecanoylphorbol 13 acetate * …   Wikipedia

  • Laminopathy — Normal nuclear lamina (a and b) and mutant nuclear lamina (c and d) from a patient with HGPS, visualized by immunofluorescence note the irregular and bumpy shape of the laminopathic nuclei[1] Laminopathies are a group of rare genetic disorders… …   Wikipedia

  • Progéria — Enfant atteint de progéria (l image en haut à droite représente un noyau cellulaire normal, celui d en bas, un noyau déformé au cours d une progéria). La progéria, ou Syndrome de Hutchinson Gilford, est une maladie génétique extrêmement rare …   Wikipédia en Français

  • Progeria — Niño con Sindrome de Progeria Clasificación y recursos externos CIE 10 …   Wikipedia Español

  • SCH 66336 — An anticancer drug that belongs to the family of drugs called enzyme inhibitors. Also called lonafarnib …   English dictionary of cancer terms

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”